作者
Maryam Hamzeh-Mivehroud, Ali Akbar Alizadeh, Michael B Morris, W Bret Church, Siavoush Dastmalchi
发表日期
2013/12/1
来源
Drug discovery today
卷号
18
期号
23-24
页码范围
1144-1157
出版商
Elsevier Current Trends
简介
Highlights
- We review phage display for use in producing therapeutic peptides/peptidomimetics.
- Generation of diverse peptide/protein phage libraries (∼ 10 9 clones) is outlined.
- Phage-displayed peptides binding therapeutic targets can be quickly identified.
- This approach provides rapid entry into the drug development pipeline.
- Phage themselves can act as carriers for both peptide and small-molecule drugs.
- Full potential of phage display in peptide-based drug discovery is not yet fulfilled.
Phage display represents an important approach in the development pipeline for producing peptides and peptidomimetics therapeutics. Using randomly generated DNA sequences and molecular biology techniques, large diverse peptide libraries can be displayed on the phage surface. The phage library can be incubated with a target of interest and the phage which bind can be isolated and sequenced to reveal the displayed …
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M Hamzeh-Mivehroud, AA Alizadeh, MB Morris… - Drug discovery today, 2013
