作者
Sara J Duncan, Sabine Grüschow, Dudley H Williams, Carole McNicholas, Ravinder Purewal, Michaela Hajek, Martin Gerlitz, Steven Martin, Stephen K Wrigley, Michael Moore
发表日期
2001/1/31
期刊
Journal of the American Chemical Society
卷号
123
期号
4
页码范围
554-560
出版商
American Chemical Society
简介
Wild-type p53 plays a crucial role in the prevention of cancer. Since dysfunction of p53 can be caused by increased levels of the protein MDM2, small molecules which antagonize the interaction between these two proteins have potential in cancer therapy. The discovery and structure determination of a fungal metabolite, chlorofusin, which antagonizes the p53/MDM2 interaction are reported.
引用总数
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SJ Duncan, S Grüschow, DH Williams, C McNicholas… - Journal of the American Chemical Society, 2001