作者
Yulong Kong, Kui Zeng, Ying Zhang, Jinning Shao, Jiaqi Yan, Jia-Yu Liao, Wenchao Wang, Xiaoyang Dai, Qinjie Weng, Shao Q Yao, Su Zeng, Linghui Qian
发表日期
2022
期刊
Chemical Communications
卷号
58
期号
9
页码范围
1314-1317
出版商
Royal Society of Chemistry
简介
Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its “always” positive charge. Herein, we developed pH-responsive CPDIMD that executes tumor targeting delivery via protonation of imidazole groups within the acidic tumor microenvironment.
学术搜索中的文章
Y Kong, K Zeng, Y Zhang, J Shao, J Yan, JY Liao… - Chemical Communications, 2022