作者
Liong Liem, Eric Van Dongen, Frank J Huygen, Peter Staats, Jeff Kramer
发表日期
2016/7/1
来源
Regional Anesthesia & Pain Medicine
卷号
41
期号
4
页码范围
511-519
出版商
BMJ Publishing Group Ltd
简介
Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:
- Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.
- Ablation or modulation of the DRG via continuous thermal …
学术搜索中的文章
L Liem, E Van Dongen, FJ Huygen, P Staats, J Kramer - Regional Anesthesia & Pain Medicine, 2016