作者
Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kiwamu Matsuoka, Kenji Tagai, Yasunori Sano, Yasuharu Yamamoto, Hitoshi Shimada, Yuhei Takado, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-ichiro Hashimoto, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Hidehiko Takahashi, Nobumasa Kato, Makoto Higuchi
发表日期
2020/12
期刊
Cerebral Cortex
卷号
30
期号
12
页码范围
6458-6468
出版商
Oxford University Press
简介
Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, and temporal cortex) or NAT (thalamus and pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex and temporal cortex) and the “attention to detail” subscale score of the Autism Spectrum Quotient. Further, there …
学术搜索中的文章
M Kubota, J Fujino, S Tei, K Takahata, K Matsuoka… - Cerebral Cortex, 2020