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Advance Access Publication Date: 16 January 2020 Data Resource Profile geographically organized into Primary Healthcare Districts (around 5000–25 000 people served by one Primary Care Centre), which in turn are embedded into Healthcare Departments (about 150 000–250 000 people served by one public hospital). Each regional NHS develops and operates its own information systems and the development of real-world data (RWD) research capabilities is heterogeneous, the Valencia Health System (VHS) in the region of Valencia being among the best in terms of data availability and the linkage capacity of databases at a population level.