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Malaria disease is caused by the plasmodium organism transmitted into humans by the female anopheles mosquito. The effect of chloroquine, artesunate or Phyllantus amarus alone or combined with vitamins A, B, C or K on male fertility indices has received no attention. Hence this study was designed to investigate the effect of chloroquine, artesunate or seed extract of Phyllanthus amarus with or without vitamins A, B, C or E on testosterone levels, sperm motility, morphology, viability and count in mice infected with Plasmodium berghei. Four days following inoculation of adult male mice with Plasmodium berghei, the mice were treated with artesunate, chloroquine or Phyllanthus amarus seed extract alone or in combination with vitamins A, B, C or E once daily. Thereafter the mice were sacrificed and semen was collected for the determination of sperm count, motility, morphology and viability and blood sample …