作者
Federico Martinón-Torres, Scott A Halperin, Terry Nolan, Bruce Tapiéro, Kirsten P Perrett, Ignacio Salamanca de la Cueva, José García-Sicilia, Zbynek Stranak, Otto G Vanderkooi, Pavel Kosina, Sarka Rumlarova, Miia Virta, Jose M Merino Arribas, Mariano Miranda-Valdivieso, Begoña Arias Novas, Jan Bozensky, María José Cilleruelo Ortega, Jose Tomas Ramos Amador, Manuel Baca, Esperanza Escribano Palomino, Gian Vincenzo Zuccotti, Jan Janota, Paola Giovanna Marchisio, Lusine Kostanyan, Nadia Meyer, Maria Angeles Ceregido, Brigitte Cheuvart, Sherine O Kuriyakose, Narcisa Mesaros
发表日期
2021/3/12
期刊
Vaccine
卷号
39
期号
11
页码范围
1598-1608
出版商
Elsevier
简介
Background
Transplacentally transferred antibodies induced by maternal pertussis vaccination interfere with infant immune responses to pertussis primary vaccination. We evaluated whether this interference remains in toddlers after booster vaccination.
Methods
In a prior phase IV, observer-blind, placebo-controlled, randomized study (NCT02377349), pregnant women in Australia, Canada and Europe received intramuscular tetanus-reduced-antigen-content diphtheria-three-component acellular pertussis vaccine (Tdap group) or placebo (control group) at 270/7–366/7 weeks’ gestation, with crossover immunization postpartum. Their infants were primed (study NCT02422264) and boosted (at 11–18 months; current study NCT02853929) with diphtheria-tetanus-three-component acellular pertussis-hepatitis B virus-inactivated poliovirus/Haemophilus influenzae type b vaccine (DTaP-HepB-IPV/Hib) and 13-valent …
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F Martinón-Torres, SA Halperin, T Nolan, B Tapiéro… - Vaccine, 2021