作者
Maryam Saberi Karimian, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar
发表日期
2017/2/1
来源
Cytokine & growth factor reviews
卷号
33
页码范围
55-63
出版商
Pergamon
简介
Monocyte chemoattractant/chemotactic protein-1 (MCP-1), a member of the CC chemokine family, is one of the key chemokines that regulate migration and tissue infiltration of monocytes/macrophages. Its role in the pathophysiology of several inflammatory diseases has been widely recognized, thus making MCP-1 a possible target for anti-inflammatory treatments. Curcumin (diferuloylmethane) is a natural polyphenol derived from the rhizomes of Curcuma Longa L. (turmeric). Anti-inflammatory action underlies numerous pharmacological effects of curcumin in the control and prevention of several diseases. The purpose of this review is to evaluate the effects of curcumin on the regulation of MCP-1 as a key mediator of chemotaxis and inflammation, and the biological consequences thereof. In vitro studies have shown that curcumin can decrease MCP-1 production in various cell lines. Animal studies have also …
学术搜索中的文章
MS Karimian, M Pirro, M Majeed, A Sahebkar - Cytokine & growth factor reviews, 2017