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Odontonema cuspidatum (Nees) Kuntze is commonly known as cardinal’s guard, mottled toothedthread and fire spike. It is a perennial shrub belonging to family Acanthaceae. It is native to Mexico and widely cultivated in tropical and subtropical areas as an ornamental plant for its attractive red flowers. The present investigation attempts to study the Pharmacognostical features of the aerial parts (leaf, stem and flower) of Odontonema cuspidatum (Nees) Kuntze. Pharmacognostical evaluation includes macroscopic, microscopy (for leaf, stem and flower) and surface preparation (for leaf and stem). This study will be useful in establishing Pharmacognostical standard measure which helps in identification and classification of the plant.