作者
Valentina M Cambuli, Michela Incani, Efisio Cossu, Tiziana Congiu, Francesca Scano, Sabrina Pilia, Federica Sentinelli, Claudio Tiberti, M Gisella Cavallo, Sandro Loche, Marco G Baroni
发表日期
2010/4/1
期刊
Diabetes Care
卷号
33
期号
4
页码范围
820-822
出版商
American Diabetes Association
简介
OBJECTIVE
Little is known about the prevalence of β-cell autoantibodies in children with excess body weight. The prevalence of type 1 diabetes autoantibodies and its relation with hyperglycemia was analyzed in 686 overweight/obese children and adolescents.
RESEARCH DESIGN AND METHODS
All children underwent an oral glucose tolerance test, and anti-GAD, anti-IA2, and anti-IAA autoantibodies were measured. Autoantibody prevalence was evaluated in 107 normal-weight children for comparison.
RESULTS
A single autoantibody was present in 2.18% of overweight/obese subjects and 1.86% normal-weight subjects (P = NS). Postload glycemia was significantly higher in antibody-positive children (133 ± 69.9 vs. 105.4 ± 17.7 mg/dl, P < 0.0001) compared with autoantibody-negative subjects. No difference in autoantibody distribution was seen when our cohort was stratified by age, sex, SDS-BMI, pubertal …
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VM Cambuli, M Incani, E Cossu, T Congiu, F Scano… - Diabetes Care, 2010