作者
F Sentinelli, L Bertoccini, I Barchetta, D Capoccia, M Incani, MG Pani, S Loche, F Angelico, M Arca, S Morini, E Manconi, A Lenzi, E Cossu, F Leonetti, MG Baroni, MG Cavallo
发表日期
2016/5/1
期刊
Nutrition, Metabolism and Cardiovascular Diseases
卷号
26
期号
5
页码范围
407-413
出版商
Elsevier
简介
Background and aims
1α,25-dihydroxyvitamin-D3, the biologically active vitamin D, plays a central role in several metabolic pathways through the binding to the vitamin D receptor (VDR). VDR has been shown to be involved in cardiovascular diseases, cancer, autoimmunity and type 2 diabetes mellitus (T2DM).
Several polymorphisms in the VDR gene have been described. Among these, the rs11568820 G-to-A nucleotide substitution was found to be functional, modulating the transcription of the VDR gene.
Objective of this study was to perform an association study between rs11568820 polymorphism and T2DM in a cohort of Italian adults with T2DM and in non-diabetic controls. To add further insight into the role of VDR gene we explored whether this association begins early in life in overweight/obese children, or becomes manifest only in adulthood.
Methods and results
As many as 1788 adults and 878 children …
学术搜索中的文章
F Sentinelli, L Bertoccini, I Barchetta, D Capoccia… - Nutrition, Metabolism and Cardiovascular Diseases, 2016