作者
Russell Fletcher, Helene Baribault, Mehaben Patel, Jacqueline Phipps, Shalaka Deshmukh, Darshini Shah, Asmiti Sura, Suhani Gupta, Hui Chen, Jay Ye, Jay Tibbitts, Geertrui F Vanhove, Wen-Chen Yeh, Yang Li, Chenggang Lu
发表日期
2021/5/1
期刊
Gastroenterology
卷号
160
期号
6
页码范围
S-799-S-800
出版商
WB Saunders
简介
Fr367 IL-1b-INDUCED SLC7A11 OVEREXPRESSION FACILITATES HEPATOCELLULAR CARCINOMA METASTASIS THROUGH UPREGULATING PD-L1 AND CSF1 EXPRESSION Limin Xia Background and aims: Inflammation promotes hepatocellular carcinoma (HCC) metastasis, and metastasis is still a major reason for HCC-associated death. However, the mechanism underlying inflammation-mediated HCC metastasis remains unclear. Here, we elucidated the function of solute carrier family 7 member 11 (SLC7A11) in inflammation-related HCC metastasis. Methods: SLC7A11, programmed death-1-ligand 1 (PD-L1), and colony stimulating factor-1 (CSF1) expression in humanHCC tissues were detected by immunohisto-chemistry. Kaplan-Meier analysis and Multivariate Cox proportional hazards model were used to assess the clinical significance of SLC7A11. Chromatin immunoprecipitation and luciferase …
学术搜索中的文章
R Fletcher, H Baribault, M Patel, J Phipps, S Deshmukh… - Gastroenterology, 2021