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Chronological aging leads to changes in several physiological process, including vascular function. All blood vessels, including conduit and resistance arteries, develop age‐related impairment in vascular relaxation that is possibly due to endothelium dysfunction and less bioavailability of endothelium‐derived factors such as nitric oxide (NO). We studied vascular responses using aorta from aged female mice that were maintained on four different diets from weaning until 30 months: normal chow (NC), high‐fat diet (HFD), NC + grape supplement (NCG) and HFD + grape supplement (HFDG). Ex‐vivo experiments with aorta using an organ bath showed that HFD had the lowest relaxation when exposed to 10 μM acetylcholine (27.12 ± 7.53%), followed by NC (45.45 ± 5.61%; p = 0.098 NC vs. HFD). The grape supplemented group NCG had higher relaxation than nonsupplement NC (70 ± 24.25%; p >0.05). HFDG …