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Animal models of asthma have shown that limonene (terpene in citrus fruits) reduces inflammation and airway reactivity. We have shown a role for A_2A adenosine receptors (A_2AAR) in mediating these effects in asthma. We investigated the effects of limonene (in vivo administration) on isolated tracheal and aortic rings to determine tissue‐specific reactivity using organ bath experiments. Mice were divided into control (CON) and allergen sensitized‐challenged (SEN) groups, and were sensitized i.p. on days 1, 6 with 20μg ovalbumin (OVA) followed by 5% OVA aerosol challenges on days 11–13 (n=4–6 mice per group). Limonene was administered as an inhalation prior to allergen challenges in one group of allergic (SEN+LIM). Response (contraction) to methacholine (MCh; 0.1μM) in isolated trachea was significantly higher in SEN tissues (225.99±67.34% vs 5.57±19.74% in CON). Treatment with limonene …