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Advanced designs and controls of heating, ventilating and air conditioning (HVAC) systems are being implemented to improve energy efficiency and thermal comfort of buildings. 1–6 Effective design and control of indoor environment requires accurate and rapid predictions. Computational fluid dynamics (CFD) is an important tool for predicting airflows and pollutants transport in the indoor environment. 1, 5, 6 However, when the targeted flow domain is large or the air flow is complex, CFD simulation would require a large amount of computing meshes. 1 Consequently, a very long computing time of several days or months is needed. CFD has been widely applied in the design and optimum operation of HVAC system for the control of the indoor environment. 2, 7 However, utilization of CFD in practical engineering design (eg a whole building with hundreds of rooms) is very challenging and difficult due to …