作者
Cristiane Ritter, Michael Andrades, Mário Luis C Frota, Fernanda Bonatto, Ricardo A Pinho, Manuela Polydoro, Fábio Klamt, Cleovaldo TS Pinheiro, Sérgio S Menna-Barreto, José Cláudio F Moreira, Felipe Dal-Pizzol
发表日期
2003/10
期刊
Intensive care medicine
卷号
29
页码范围
1782-1789
出版商
Springer-Verlag
简介
Objective
This study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality.
Design and setting
Prospective animal study in a university laboratory for experimental.
Subjects
140 male Wistar rats.
Interventions
The animals were randomly divided into three groups: sham-operated (n=20), cecal ligation and perforation resuscitated with normal saline (n=40), and cecal ligation and perforation with normal saline plus antibiotics (n=40).
Measurements and results
Blood samples were collected from all animals 3, 12, and 24 h after CLP through a jugular catheter inserted before CLP. Rats were evaluated during 5 days after the …
引用总数
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C Ritter, M Andrades, MLC Frota, F Bonatto, RA Pinho… - Intensive care medicine, 2003