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Stress-induced hyperthermia is an acute response that occurs in the short term in individuals who are facing a stressful stimulus, considering that this response can provide significant information on stress degree. However, it is not yet clear whether the neurological pathway can be modified to the degree to which stress is perceived. Furthermore, there is not enough information as to how factors that modify perception stress degree act on stress-induced Hyperthermia. Besides, research indicates that the thermal response possibly has a greater cardiovascular influence by generating energy resource consumption. In the same way, the factors that induce this response have been questioned, since recent evidence indicates that social factors such as the presence of conspecifics attenuate the thermal response, but, when coexistence or some other action like parenting is prevented, the response is to the reverse. For this reason, the objective of this article was to analyze the neurobiology of stress-induced hyperthermia and its conceptual difference with infectious fever, as well as to integrate the factors that modulate it, analyzing recent scientific advances in stress-induced thermal response.