作者
Takuya Seike, Eishiro Mizukoshi, Kazutoshi Yamada, Hikari Okada, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Taro Yamashita, Yoshio Sakai, Masao Honda, Kenichi Harada, Shuichi Kaneko
发表日期
2020/7
期刊
Journal of Gastroenterology
卷号
55
页码范围
701-711
出版商
Springer Singapore
简介
Background
The interaction between T-cells/fatty acids involved in non-alcoholic fatty liver disease (NAFLD) and liver fibrosis progression is poorly understood. In this study, we conducted a comprehensive analysis of T-cell profiles of NAFLD patients to better understand their relationship with fatty acids and relevance to liver fibrosis.
Methods
We analyzed the differences in T-cell profiles of peripheral blood mononuclear cells (PBMCs) between 40 NAFLD patients and 5 healthy volunteers (HVs), and their relationship with liver fibrosis stage or progression. Moreover, we analyzed the relationship between T-cell profiles and fatty acid compositions in vivo, and changes in T-cell profiles after treatment with fatty acids in vitro.
Results
T-cell profiles of NAFLD patients were different from those of HVs. The CD25+CD45+CD4+ T-cell frequency was increased in NAFLD patients with high liver fibrosis stage and …
学术搜索中的文章
T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara… - Journal of Gastroenterology, 2020