作者
HY Zaki, KH Leung, WC Yiu, N Gasmelseed, NEM Elwali, Shea Ping Yip
发表日期
2012/7/1
期刊
The International journal of tuberculosis and lung disease
卷号
16
期号
7
页码范围
934-940
出版商
International Union Against Tuberculosis and Lung Disease
简介
SETTING
Host genetic risk factors influence susceptibility to tuberculosis (TB). There is ample evidence supporting the involvement of toll-like receptor 4 (TLR4) in mycobacterial infection.
OBJECTIVE
To study the relationship between the TLR4 gene and TB susceptibility in the Sudanese population.
DESIGN
A case-control study was conducted among 207 patients with pulmonary TB and 395 healthy controls. Ten tag single nucleotide polymorphisms (SNPs) of the TLR4 gene were genotyped using restriction digestion or hybridisation assays, and analysed.
RESULTS
The genotypes were in Hardy-Weinberg equilibrium. After controlling for sex using the Mantel-Haenszel test, four SNPs showed significant differences between cases and controls, even after correction of multiple comparisons by Bonferroni procedure. The Mantel-Haenszel estimates of allelic odds ratios for the high-risk alleles were 1.67 for rs1927911 …
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HY Zaki, KH Leung, WC Yiu, N Gasmelseed… - The International journal of tuberculosis and lung …, 2012