作者
Kevin Croce, Huiyun Gao, Yunmei Wang, Toshifumi Mooroka, Masashi Sakuma, Can Shi, Galina K Sukhova, René RS Packard, Nancy Hogg, Peter Libby, Daniel I Simon
发表日期
2009/8/4
期刊
Circulation
卷号
120
期号
5
页码范围
427-436
出版商
Lippincott Williams & Wilkins
简介
Background— Myeloid-related protein (MRP)-8 (S100A8) and MRP-14 (S100A9) are members of the S100 family of calcium-modulated proteins that regulate myeloid cell function and control inflammation, in part, through activation of Toll-like receptor-4 and the receptor for advanced glycation end products. A transcriptional profiling approach in patients with acute coronary syndromes identified MRP-14 as a novel predictor of myocardial infarction. Further studies demonstrated that elevated plasma levels of MRP-8/14 heterodimer predict increased risk of first and recurrent cardiovascular events. Beyond its serving as a risk marker, whether MRP-8/14 participates directly in vascular inflammation and disease remains unclear.
Methods and Results— We evaluated vascular inflammation in wild-type and MRP-14–deficient (MRP-14−/−) mice that lack MRP-8/14 complexes with experimental arterial injury, vasculitis …
引用总数
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