作者
Islam Eljilany, Mohamed Elarref, Nabil Shallik, Abdel-Naser Elzouki, Loulia Bader, Ahmed El-Bardissy, Osama Abdelsamad, Daoud Al-Badriyeh, Larisa H Cavallari, Hazem Elewa
发表日期
2021/8/28
期刊
Pharmacogenomics and Personalized Medicine
页码范围
1069-1080
出版商
Taylor & Francis
简介
Background
Annually, 10% of warfarin patients will likely need to stop warfarin prior to elective surgery to achieve a baseline international normalization ratio (INR) level (INR ≤ 1.2) at the time of the procedure. This study explores the influence of genetic and non-genetic factors on INR normalization in the Arab (major part of Near Eastern) population in preprocedural warfarin management.
Methods
An observational prospective cohort study was designed to recruit Arab patients taking warfarin and scheduled for an elective procedure. Two INR readings were recorded. DNA extraction and genotyping of variants in CYP2C9*2, CYP2C9*3, CYP4F2*3, VKORC1*2, and FII (rs5896) and FVII (rs3093229) genes using real-time polymerase chain reaction were performed.
Results
Data from 116 patients were included in the analysis. CYP2C9 and VKORC1 genetic variants carriers required lower maintenance dose …
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I Eljilany, M Elarref, N Shallik, AN Elzouki, L Bader… - Pharmacogenomics and Personalized Medicine, 2021
