作者
Alka Hasani, Vajihe Sheikhalizadeh, Mohammad Ahangarzadeh Rezaee, Mohammad Rahmati-Yamchi, Akbar Hasani, Reza Ghotaslou, Hamid Reza Goli
发表日期
2016/7/1
期刊
Microbial Drug Resistance
卷号
22
期号
5
页码范围
347-353
出版商
Mary Ann Liebert, Inc.
简介
We evaluated aminoglycoside resistance in 87 Acinetobacter baumannii strains isolated from four hospitals located in the North West region of Iran and typed them in sequence groups (SGs) using trilocus sequence-based scheme to compare their clonal relationships with international clones. Resistance toward aminoglycosides was assayed by minimum inhibitory concentration (MIC) and presence of aminoglycoside-modifying enzymes (AMEs), and ArmA-encoding genes were evaluated in different SGs. The majority of isolates belonged to SG1 (39%), SG2 (33.3%), and SG3 (12.6%), whereas the remaining ones were assigned to six novel variants of SGs. MIC determination revealed netilmicin as the most and kanamycin as the least active aminoglycosides against all groups. Among the varied SGs, isolates of SG2 showed more susceptibility toward all tested aminoglycosides. APH(3′′)-VIa-encoding gene …
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