作者
James M Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm, Maija Holsti, Lynn Babcock, Alex Rogers, William Barsan, James Cloyd, Daniel Lowenstein, Thomas P Bleck, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan B Fountain, Ellen Underwood, Jason T Connor, Robert Silbergleit, Emily Gray, Sonya Gunter, Amy Fansler, Valerie Stevenson, Erin Bengelink, Deneil Harney, Mickie Speers, Joy Black, Natalie Fisher, Donna Harsh, Arthi Ramakrishnan, Lindsey Harris, Nia Bozeman, Aimee Spiteri, Yuko Palesch, Holly Tillman, Wenle Zhao, Qi Pauls, Chris Arnaud, Catherine R Dillon, Jodie Riley, Teldon Alford, Cassidy Conner, Lisa Coles, Abhi Sathe, Scott Janis, Adam Hartman, Brandy Fureman, Eugen Trinka, David Treiman, David Wright, Jonathan Ratcliff, Alex Hall, Alaina Williams, Harold Simon, Nicholas Stanley, Roger Humphries, Theresa Mims, Joann Short, Elizabeth Jones, Misty Ottman, Nina Gentile, Derek Isenberg, Hannah Reimer, Vernon Sayoc Kalugdan, Claude Hemphill, Debbie Yi Madhok, Jeany Duncan, Dominica Randazzo, James Quinn, Anita Visweswaran, Rosen Mann, Opeolu Adeoye, Jason McMullan, Brandon Foreman, Sara Keegan, Michelle Biros, Brian Driver, Audrey Hendrickson, Jamie Stang, Christopher Lewandowski, Joseph Miller, Kaleem Chaudhry, Shannen Berry, Craig Warden, Rachel Blake, Jennifer NB Cook, Erin Sabolick, Antoine Selman, Katrina Kissman, Monica Moore, J Stephen Huff, Lea Becker, Jan Claassen, Angela Velazquez, Cristina Falo, Zlatan Coralic, Jackie Grupp-Phelan, Jill Baren, Angela Ellison, Ashley Woodford, Ima Samba, Marlena Kittick, Ralph Riviello, John Massey, Lisa Bonacquisti, Steven Levine, Sergey Motov, Christian Fromm, Rukhsana Hossain, Antonios Likourezos, Illya Pushkar, Thomas Terndrup, Salman Khaliqdina, Michael Hill, Bjorn Peterson, Alexia Terwilliger, Joseph Holm, Kyra Wicklund, Sandi Wewerka, Robert Welch, Claire Pearson, Vijaya Arun Kumar, Farhan Ayaz, Saikat Bhuiyan, Valerie H Mika, Lola Morgan, Floyd Jones, Lorraine Dishman, Thomas Henry, Ford Erickson, Abbey Staugaitis, Chloe Lawyer, Kathleen Miller, Clif Callaway, Alexandra Urban, Sara DiFiore, Peter Adams, Brian Baum, Jason Nomura, Barbara Davis, Tom Aufderheide, Amanda Emmrich, Melissa Mena, Jacob Labinski, Chinwe Ogedegbe, Diana McCarthy, Arelis Villot-Santiago, Joshua Goldstein, Eric S Rosenthal, Abigail Cohen, Chen Mei Su
发表日期
2020/4/11
期刊
The Lancet
卷号
395
期号
10231
页码范围
1217-1224
出版商
Elsevier
简介
Background
Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups.
Methods
In this multicentre, double-blind, response-adaptive, randomised controlled trial, we recruited patients from 58 hospital emergency departments across the USA. Patients were eligible for inclusion if they were aged 2 years or older, had been treated for a generalised convulsive seizure of longer than 5 min duration with adequate doses of benzodiazepines, and continued to …
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JM Chamberlain, J Kapur, S Shinnar, J Elm, M Holsti… - The Lancet, 2020