作者
Tinh-Hai Collet, Jacobijn Gussekloo, Douglas C Bauer, Wendy PJ den Elzen, Anne R Cappola, Philippe Balmer, Giorgio Iervasi, Bjørn O Åsvold, Jose A Sgarbi, Henry Voelzke, Bariş Gencer, Rui MB Maciel, Sabrina Molinaro, Alexandra Bremner, Robert N Luben, Patrick Maisonneuve, Jacques Cornuz, Anne B Newman, Kay-Tee Khaw, Rudi GJ Westendorp, Jayne A Franklyn, Eric Vittinghoff, John P Walsh, Nicolas Rodondi, for the Thyroid Studies Collaboration
发表日期
2012/5/28
来源
Archives of internal medicine
卷号
172
期号
10
页码范围
799-809
出版商
American Medical Association
简介
Background
Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts.
Methods
Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 participants from 6 cohorts with available data, and incident AF was analyzed in 8711 participants from 5 cohorts. Euthyroidism was defined as thyrotropin level between 0.45 and 4.49 mIU/L and endogenous subclinical hyperthyroidism as thyrotropin level lower than 0.45 mIU/L with normal free thyroxine levels, after excluding those receiving thyroid-altering medications.
Results
Of 52 674 participants, 2188 …
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TH Collet, J Gussekloo, DC Bauer, WPJ den Elzen… - Archives of internal medicine, 2012