作者
Bovine Genome Sequencing and Analysis Consortium, Christine G Elsik, Ross L Tellam, Kim C Worley, Richard A Gibbs, Donna M Muzny, George M Weinstock, David L Adelson, Evan E Eichler, Laura Elnitski, Roderic Guigó, Debora L Hamernik, Steve M Kappes, Harris A Lewin, David J Lynn, Frank W Nicholas, Alexandre Reymond, Monique Rijnkels, Loren C Skow, Evgeny M Zdobnov, Lawrence Schook, James Womack, Tyler Alioto, Stylianos E Antonarakis, Alex Astashyn, Charles E Chapple, Hsiu-Chuan Chen, Jacqueline Chrast, Francisco Câmara, Olga Ermolaeva, Charlotte N Henrichsen, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, Felix Kokocinski, Melissa Landrum, Donna Maglott, Kim Pruitt, Victor Sapojnikov, Stephen M Searle, Victor Solovyev, Alexandre Souvorov, Catherine Ucla, Carine Wyss, Juan M Anzola, Daniel Gerlach, Eran Elhaik, Dan Graur, Justin T Reese, Robert C Edgar, John C McEwan, Gemma M Payne, Joy M Raison, Thomas Junier, Evgenia V Kriventseva, Eduardo Eyras, Mireya Plass, Ravikiran Donthu, Denis M Larkin, James Reecy, Mary Q Yang, Lin Chen, Ze Cheng, Carol G Chitko-McKown, George E Liu, Lakshmi K Matukumalli, Jiuzhou Song, Bin Zhu, Daniel G Bradley, Fiona SL Brinkman, Lilian PL Lau, Matthew D Whiteside, Angela Walker, Thomas T Wheeler, Theresa Casey, J Bruce German, Danielle G Lemay, Nauman J Maqbool, Adrian J Molenaar, Seongwon Seo, Paul Stothard, Cynthia L Baldwin, Rebecca Baxter, Candice L Brinkmeyer-Langford, Wendy C Brown, Christopher P Childers, Timothy Connelley, Shirley A Ellis, Krista Fritz, Elizabeth J Glass, Carolyn TA Herzig, Antti Iivanainen, Kevin K Lahmers, Anna K Bennett, C Michael Dickens, James GR Gilbert, Darren E Hagen, Hanni Salih, Jan Aerts, Alexandre R Caetano, Brian Dalrymple, Jose Fernando Garcia, Clare A Gill, Stefan G Hiendleder, Erdogan Memili, Diane Spurlock, John L Williams, Lee Alexander, Michael J Brownstein, Leluo Guan, Robert A Holt, Steven JM Jones, Marco A Marra, Richard Moore, Stephen S Moore, Andy Roberts, Masaaki Taniguchi, Richard C Waterman, Joseph Chacko, Mimi M Chandrabose, Andy Cree, Marvin Diep Dao, Huyen H Dinh, Ramatu Ayiesha Gabisi, Sandra Hines, Jennifer Hume, Shalini N Jhangiani, Vandita Joshi, Christie L Kovar, Lora R Lewis, Yih-shin Liu, John Lopez, Margaret B Morgan, Ngoc Bich Nguyen, Geoffrey O Okwuonu, San Juana Ruiz, Jireh Santibanez, Rita A Wright, Christian Buhay, Yan Ding, Shannon Dugan-Rocha, Judith Herdandez, Michael Holder, Aniko Sabo, Amy Egan, Jason Goodell, Katarzyna Wilczek-Boney, Gerald R Fowler, Matthew Edward Hitchens
发表日期
2009/4/24
期刊
Science
卷号
324
期号
5926
页码范围
522-528
出版商
American Association for the Advancement of Science
简介
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
引用总数
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