作者
Pradeep S Tanwar, Tomoko Kaneko-Tarui, LiHua Zhang, Jose M Teixeira
发表日期
2012/10/15
期刊
Human molecular genetics
卷号
21
期号
20
页码范围
4394-4405
出版商
Oxford University Press
简介
Male patients with Peutz–Jeghers syndrome (PJS) have defective spermatogenesis and are at increased risk of developing Sertoli cell tumors. Mutations in the Liver Kinase B1 (LKB1/STK11) gene are associated with the pathogenesis of PJS and have been identified in non-PJS patients with sporadic testicular cancers. The mechanisms controlled by LKB1 signaling in Sertoli cell functions and testicular biology have not been described. We have conditionally deleted the Lkb1 gene (Lkb1cko) in somatic testicular cells to define the molecular mechanisms involved in the development of the testicular phenotype observed in PJS patients. Focal vacuolization in some of the seminiferous tubules was observed in 4-week-old mutant testes but germ cell development appeared to be normal. However, similar to PJS patients, we observed progressive germ cell loss and Sertoli cell only tubules in Lkb1cko testes from …
学术搜索中的文章
PS Tanwar, T Kaneko-Tarui, LH Zhang, JM Teixeira - Human molecular genetics, 2012