作者
Stefano Bonassi, Monica Neri, Cecilia Lando, Marcello Ceppi, Yi-ping Lin, Wushou P Chang, Nina Holland, Micheline Kirsch-Volders, Errol Zeiger, Michael Fenech, HUMN Collaborative Group
发表日期
2003/3/1
期刊
Mutation Research/Reviews in Mutation Research
卷号
543
期号
2
页码范围
155-166
出版商
Elsevier
简介
The effect of tobacco smoking on the frequency of micronuclei (MN) in human lymphocytes has been the object of many population studies. In most reports, the results were unexpectedly negative, and in many instances smokers had lower frequencies of MN than non-smokers. A pooled re-analysis of 24 databases from the HUMN international collaborative project has been performed with the aim of understanding the impact of smoking habits on MN frequency. The complete database included 5710 subjects, with 3501 non-smokers, 1409 current smokers, and 800 former smokers, among subjects in occupational and environmental surveys. The overall result of the re-analysis confirmed the small decrease of MN frequencies in current smokers (frequency ratio (FR)=0.97, 95% confidence interval (CI)=0.93–1.01) and in former smokers (FR=0.96, 95% CI=0.91–1.01), when compared to non-smokers. MN frequency …
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S Bonassi, M Neri, C Lando, M Ceppi, Y Lin… - Mutation Research/Reviews in Mutation Research, 2003