作者
Monica Neri, Donatella Ugolini, Stefano Bonassi, Alexandra Fucic, Nina Holland, Lisbeth E Knudsen, Radìm J Šrám, Marcello Ceppi, Vittorio Bocchini, Domenico Franco Merlo
发表日期
2006/1/1
来源
Mutation Research/Reviews in Mutation Research
卷号
612
期号
1
页码范围
14-39
出版商
Elsevier
简介
The present review is based on findings from 178 publications retrieved through an extensive search of the MedLine/PubMed database for a 25 years time period (1980–2004) and 10 manually identified papers. Among the cytogenetic biomarkers that are frequently used in field studies, chromosome aberrations (CA) and micronuclei (MN) but not sister chromatid exchanges (SCE) were found consistently increased in children exposed to environmental pollutants. Meta-analysis of the studies reporting SCE in cord blood showed similar levels of SCE in exposed and in non-exposed newborns. Exposure to airborne pollutants, soil and drinking water contaminants, mostly increased CA and, to a lesser extent, MN levels in children. The effect of exposure to airborne urban pollutants was consistently reported by field studies measuring DNA, albumin and hemoglobin adducts. Prenatal (in utero) and postnatal exposure …
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M Neri, D Ugolini, S Bonassi, A Fucic, N Holland… - Mutation Research/Reviews in Mutation Research, 2006