作者
Luana U Pagan, Ricardo L Damatto, Mariana J Gomes, Aline RR Lima, Marcelo DM Cezar, Felipe C Damatto, David RA Reyes, Tulio MM Caldonazo, Bertha F Polegato, Marina P Okoshi, Katashi Okoshi
发表日期
2019/9
期刊
Journal of Cellular and Molecular Medicine
卷号
23
期号
9
页码范围
6504-6507
简介
We evaluated the influence of aerobic training on cardiac remodeling in untreated spontaneously hypertensive rats (SHR). Four experimental groups were used: sedentary (W‐SED, n=27) and trained (WEX, n=31) normotensive Wistar rats, and sedentary (SHR‐SED, n=27) and exercised (SHR‐EX, n=32) hypertensive rats. At 13 months old, trained groups underwent treadmill exercise five days a week for four months. Statistical analysis: ANOVA or Kruskal‐Wallis. Exercised groups had higher physical capacity. Hypertensive groups presented left ventricular (LV) concentric hypertrophy with impaired function. Left atrium diameter, LV posterior wall thickness and relative thickness, and isovolumetric relaxation time were lower in SHR‐EX than SHR‐SED. Interstitial collagen fraction and Type I‐Type III collagen ratio were higher in SHR‐SED than W‐SED. In SHR‐EX these parameters had intermediate values between …
引用总数
2019202020212022202320243211733
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