作者
Nara Aline Costa, Ana Lúcia Gut, José Alexandre Coelho Pimentel, Silvia Maria Franciscato Cozzolino, Paula Schmidt Azevedo, Ana Angélica Henrique Fernandes, Bertha Furlan Polegato, Suzana Erico Tanni, Rafael Dezen Gaiolla, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, Marcos Ferreira Minicucci
发表日期
2014/6
期刊
Critical care
卷号
18
页码范围
1-7
出版商
BioMed Central
简介
Introduction
Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock. The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock remains unknown. Therefore, the objective of this study was to evaluate the association of erythrocyte selenium concentration with glutathione peroxidase (GPx1) activity, GPx1 polymorphisms and with ICU and hospital mortality in septic shock patients.
Methods
This prospective study included all patients older than 18 years with septic shock on admission or during their ICU stay, admitted to one of the three ICUs of our institution, from January to August 2012. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 72 hours of the patients’ admission or within 72 hours of the …
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NA Costa, AL Gut, JAC Pimentel, SMF Cozzolino… - Critical care, 2014
