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Cancer is one of the leading causes of death worldwide. Among them, colorectal cancer is linked with diet as the epithelial cells of colon and rectum come in direct contact with diet. Diets rich in phenolic constituents are associated in eradicating various noncommunicable diseases including cancer. This work illustrates antiproliferative effects of honey and its phytochemicals against colorectal cancer to limelight. Honey and its phytochemicals are found to inhibit the cancer growth. Changes like activation of caspase‐3, caspase‐8, polyadenosine diphosphate‐ribose polymerase cleavage, boost in ROS level activating mitochondrial pathway, lipid layer breakage, DNA fragmentation, increase of G0/G1 phase cells, up‐regulation of Bax regulators and p53 dependent apoptosis are significant. It is high time for scientists to initiate more trails using honey and its phytochemicals against some immune‐deficient animal …