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Interleukin 6 (IL-6) has a critical role in pain mechanisms. IL-6 signals through the Janus-activated kinases 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) pathway. The contribution of JAK2 signaling in inflammation‑induced hyperalgesia has not been addressed previously. The role of this pathway was investigated using the JAK2 inhibitor, AG490, in a rat model of inflammatory pain. Unilateral hind paw inflammatory pain was induced in male Sprague‑Dawley rats by intraplantar (i. pl.) injection of 3.5% ʎ‑carrageenan. Inflamed rats received an i. pl. injection of either 3.5% of dimethylsulfoxide or AG490 (1‑10 µg). The antinociceptive effects of AG490 were assessed by 2 pain behavioral assays 4 h later: The thermal and mechanical hyperalgesia tests. AG490 (1‑10 µg) significantly attenuated ʎ‑carrageenan‑induced thermal hyperalgesia in a dose‑dependent manner. AG490 also reduced …