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Aquaporins (AQPs) constitute a major conduit for movement of water across plasma membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and homeostasis as mutations and knockout have resulted in dominant lens cataract. Several functions have been attributed for AQP0. In vitro and ex vivo experiments from several laboratories have confirmed the water permeability function of AQP0. However, this function seems paradoxical when the lens switches protein expression from AQP1 in the equatorial epithelial cells to 40 times less efficient AQP0 in the differentiating fiber cells. A possible explanation is AQP0 may perform unique function/s besides being a water pore. Indirect evidences including those from structural studies indicate a cell-to-cell adhesion role for AQP0. However, there is a lack of experimental evidence directly demonstrating the cell-to-cell adhesion capability of AQP0 …