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Plant growth promoting rhizobacteria (PGPR) are groups of free living Rhizospheric bacteria which can enhance plant growth under normal as well as stress conditions. One of the major issues of agricultural crops is a reduction in yield by different pathogens, which affect many staple crops. So there is a need to develop some strategies for preventing the crops from different pathogens. Several PGPR such as Pseudomonas, Azospirillum, Rhizobium and Bacillus species can promote plant growth under stress condition by suppressing the growth of pathogenic organisms. PGPR stimulate plant growth by various mechanisms, for example induce systemic resistance. PGPR produce siderophores, antibiotics and degrade virulence factor against pathogenic attack, which inhibits the growth of pathogenic and protect the plant. In spite of the importance of PGPR in crop production system present review focuses on different ways adopted by PGPR to prevent crops from pathogen and increase their yield.