作者
Andrea Visentin, Laura Bonaldi, Gian Matteo Rigolin, Francesca Romana Mauro, Annalisa Martines, Federica Frezzato, Silvia Imbergamo, Edoardo Scomazzon, Stefano Pravato, Maria Antonella Bardi, Maurizio Cavallari, Eleonora Volta, Francesco Cavazzini, Maurizio Nanni, Ilaria Del Giudice, Monica Facco, Anna Guarini, Gianpietro Semenzato, Robin Foà, Antonio Cuneo, Livio Trentin
发表日期
2019/7/16
期刊
British journal of cancer
卷号
121
期号
2
页码范围
150-156
出版商
Nature Publishing Group UK
简介
Background
Complex karyotype (CK) is a heterogeneous category with a negative impact in chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients with major structural abnormalities (i.e. CK2) are characterised by a worse prognosis, as compared to other lesions within CK(CK1).
Methods
We performed a multicentre retrospective study to test whether the combination of CK subtypes with IGHV status could be a relevant prognostic and predictive tool.
Results
Among 522 patients 13% harboured CK2, 41% CK1 and/or U-IGHV (U-CK1) and 46% M-IGHV without any CK subtypes (M-noCK). After a median follow-up of 5.8 years, CK2 patients had the shortest TTFT (5-year TTFT 31%, 39 and 81%, p < 0.0001) and OS (5-year OS 67%, 85 and 93%, p < 0.0001) as compared to U-CK1 or M-noCK cases, regardless of TP53 abnormalities. CK2 patients also had the worst outcome after …
学术搜索中的文章
A Visentin, L Bonaldi, GM Rigolin, FR Mauro… - British journal of cancer, 2019