作者
Andrea Visentin, Monica Facco, Federica Frezzato, Monica Castelli, Valentina Trimarco, Veronica Martini, Cristina Gattazzo, Filippo Severin, Giorgia Chiodin, Annalisa Martines, Laura Bonaldi, Ilaria Gianesello, Elisa Pagnin, Elisa Boscaro, Francesco Piazza, Renato Zambello, Gianpietro Semenzato, Livio Trentin
发表日期
2015/10/1
期刊
Clinical Lymphoma Myeloma and Leukemia
卷号
15
期号
10
页码范围
612-620. e5
出版商
Elsevier
简介
Introduction
Several prognostic factors have been identified to predict the outcome of patients with chronic lymphocytic leukemia (CLL), but only a few studies analyzed more markers together.
Patients and Methods
Taking advantage of a population of 608 patients, we identified the strongest prognostic markers of survival and, subsequently, in a cohort of 212 patients we integrated data of cytogenetic lesions, IGHV mutational status, and CD38 expression in a new and easy scoring system we called the integrated CLL scoring system (ICSS). ICSS defines 3 groups of risk: (1) low risk (patients with 13q− or normal fluorescence in-situ hybridization analysis results, mutated IGHV, and CD38) (2) high risk (all 11q− or 17p− patients and/or all unmutated IGHV and CD38+ patients); and (3) intermediate risk (all remaining patients).
Results
Using only these 3 already available prognostic factors, we were able to properly …
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A Visentin, M Facco, F Frezzato, M Castelli, V Trimarco… - Clinical Lymphoma Myeloma and Leukemia, 2015