作者
Chun-Yang Lin, Joshua Wolf, David C Brice, Yilun Sun, Macauley Locke, Sean Cherry, Ashley H Castellaw, Marie Wehenkel, Jeremy Chase Crawford, Veronika I Zarnitsyna, Daniel Duque, Kim J Allison, E Kaitlynn Allen, Scott A Brown, Alexandra H Mandarano, Jeremie H Estepp, Aditya H Gaur, James M Hoffman, Tomi Mori, Elaine I Tuomanen, Richard J Webby, Hana Hakim, Randall T Hayden, Diego R Hijano, Walid Awad, Resha Bajracharya, Brandi L Clark, Valerie Cortez, Ronald H Dallas, Thomas Fabrizio, Pamela Freiden, Ashleigh Gowen, Jason Hodges, Allison M Kirk, Ericka Kirkpatrick Roubidoux, Robert C Mettelman, Jamie Russell-Bell, Aisha Souquette, James Sparks, Lee-Ann Van de Velde, Ana Vazquez-Pagan, Kendall Whitt, Taylor L Wilson, David E Wittman, Nicholas Wohlgemuth, Gang Wu, Charles Taylor, Carmen Molina-Paris, Stacey Schultz-Cherry, Li Tang, Paul G Thomas, Maureen A McGargill
发表日期
2022/1/12
期刊
Cell Host & Microbe
卷号
30
期号
1
页码范围
83-96. e4
出版商
Elsevier
简介
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility to SARS-CoV-2 infection or immunity following infection and vaccination. Therefore, we analyzed samples from the same individuals before and after SARS-CoV-2 infection or vaccination. We found hCCCoV antibody levels increase after SARS-CoV-2 exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline hCCCoV antibody levels are not associated with protection against SARS-CoV-2 infection. Rather, higher magnitudes of pre-existing betacoronavirus antibodies correlate with more SARS-CoV-2 antibodies following infection, an indicator of greater disease severity. Additionally, immunization with hCCCoV spike …
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CY Lin, J Wolf, DC Brice, Y Sun, M Locke, S Cherry… - Cell Host & Microbe, 2022