作者
CJ Kushner, M Tarazi, RG Gaffney, R Feng, K Ardalan, HA Brandling‐Bennett, L Castelo‐Soccio, JC Chang, YE Chiu, S Gmuca, RD Hunt, PJ Kahn, AM Knight, J Mehta, DR Pearson, JR Treat, J Wan, AC Yeguez, JSS Concha, B Patel, J Okawa, LM Arkin, VP Werth, Donald Goldsmith, Svetlana Lvovich, Megan L Curran, Marisa Klein‐Gitelman, Yasmine Kirkorian, Sarah Sertial
发表日期
2019/1/1
期刊
British Journal of Dermatology
卷号
180
期号
1
页码范围
165-171
出版商
Blackwell Publishing Ltd
简介
Background
The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a reliable outcome measure for cutaneous lupus erythematosus (CLE) in adults used in clinical trials. However, it has not been validated in children, limiting clinical trials for paediatric CLE.
Objectives
This study aimed to validate the CLASI in paediatrics.
Methods
Eleven paediatric patients with CLE, six dermatologists and six rheumatologists participated. The physicians were trained to use the CLASI and Physician's Global Assessment (PGA), and individually rated all patients using both tools. Each physician reassessed two randomly selected patients. Within each physician group, the intraclass correlation coefficient (ICC) was calculated to assess the reliability of each measure.
Results
CLASI activity scores demonstrated excellent inter …
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CJ Kushner, M Tarazi, RG Gaffney, R Feng, K Ardalan… - British Journal of Dermatology, 2019