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Laparoscopic gastric plicature (LGP) is an emerging bariatric procedure considered effective and safe for weight loss. To determine the percentage of excess of weight loss (% EWL), BMI, percentage of excess of BMI loss (% EBMI), and postoperative morbidity and mortality in a five-year follow-up of patients submitted to LGP. Analytical study based on the data of case files of patients who underwent LGP during 2012, with a five-year follow-up, and evaluations at three, six, 12, 36 and 60 postoperative months. A total of 40 patients were included, with a mean age of 36.2±8.2 years; preoperative weight and BMI were 105.8±18.9 kg and 39.2±5.5 kg/m 2, respectively. The% EWL was of 60.3% after one year, and 51.8% after 60 postoperative months. Weight, BMI,% EWL, and loss of excess BMI (% EBMI) were statistically significant in contrast to preoperative measures (p‹ 0.001). No changes were observed from 12 to 36 postoperative months. A significant regain of weight was observed from 36 to 60 postoperative months. Three reinterventions were required because of internal bleeding, and two conversions to Roux-en-Y gastric bypass. LGP is an effective bariatric procedure for weight loss, with an important% EWL observed after five years post-surgery.