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Results:

Decreased frequency of wild type genotype with respect to VEGF+ 936C/T and sFlt-1 (+ 4244G/A,− 4771G/T, and− 523C/G) polymorphisms was seen in patients. ELISA results showed lower VEGF-A (198.43±14.63 pg/ml vs. 235.08±16.72 pg/ml [mean±standard error of mean]) and higher sFlt-1 levels (2932.81 [1802.33–5760.46] pg/ml vs. 1114.94 [655.03–2694.35] Median [Range]; P< 0.05) in patients as compared to controls. Preeclamptic women with increased frequency of VEGF+ 936CT genotype had lower serum levels of VEGF-A. However, preeclamptic women with increased frequency of GA, AA, GT, TT, CG, and GG genotypes of sFlt-1 (+ 4244G/A,− 4771G/T,− 523C/G) polymorphisms had increased serum levels of sFlt-1.

Discussion and Conclusion:

The present study shows, for the first time, a possible association of VEGF and sFlt-1 polymorphisms with gene expression and altered protein levels in …