作者
Nia CS Lewis, Damian M Bailey, Gregory R Dumanoir, Laura Messinger, Samuel JE Lucas, James D Cotter, Joseph Donnelly, Jane McEneny, Ian S Young, Mike Stembridge, Keith R Burgess, Aparna S Basnet, Philip N Ainslie
发表日期
2014/3/1
期刊
The Journal of physiology
卷号
592
期号
5
页码范围
1009-1024
简介
Key points
- Information describing alterations in vascular function during either acute or prolonged normobaric or hypobaric hypoxia is sparse and often confounded by pathology and methodological limitations.
- We show that high altitude exposure in lowlanders is associated with impairments in both endothelial and smooth muscle function, and with increased central arterial stiffness; furthermore, in all of these respects, lowlanders’ vasculature becomes comparable to that of natives born and raised at altitude.
- Changes in endothelial function occur very rapidly in normobaric hypoxia, and partly under the influence of sympathetic nerve activity.
- Thus, a lifetime of high‐altitude exposure neither attenuates nor intensifies the impairments in vascular function observed with short‐term exposure in lowlanders; such impairment and altered structure likely translate into an elevated cardiovascular risk.
Abstract
Research …
学术搜索中的文章
NCS Lewis, DM Bailey, GR Dumanoir, L Messinger… - The Journal of physiology, 2014