作者
KJ Smith, D MacLeod, CK Willie, NCS Lewis, RL Hoiland, K Ikeda, MM Tymko, J Donnelly, TA Day, N MacLeod, SJE Lucas, PN Ainslie
发表日期
2014/12/15
期刊
The Journal of physiology
卷号
592
期号
24
页码范围
5507-5527
简介
Key points
- This study assessed the dynamic response of global cerebral blood flow (CBF) and cerebral fuel utilization during and following incremental supine exercise to exhaustion.
- Global CBF increased more during exercise and recovery at high altitude (HA) compared with sea level (SL) such that cerebral oxygen delivery () was maintained.
- The increase in cerebral metabolic rate of oxygen during maximal exercise at HA was half the increase observed at SL.
- Arterial lactate production during exercise at the same absolute intensities was greater at HA compared with SL, but reduced at the same relative intensities.
- Cerebral carbohydrate uptake (lactate and glucose) is greater than oxygen uptake at HA compared with SL, indicating a shift towards an increased non‐oxidative metabolic utilization.
- These results suggest that CBF increases to maintain during exercise at HA while changes in arterial lactate …
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KJ Smith, D MacLeod, CK Willie, NCS Lewis… - The Journal of physiology, 2014