作者
Jeanette Tas, Erta Beqiri, Ruud C van Kaam, Marek Czosnyka, Joseph Donnelly, Roel H Haeren, Iwan CC van der Horst, Peter J Hutchinson, Sander MJ van Kuijk, Analisa L Liberti, David K Menon, Cornelia WE Hoedemaekers, Bart Depreitere, Peter Smielewski, Geert Meyfroidt, Ari Ercole, Marcel JH Aries
发表日期
2021/10/15
期刊
Journal of neurotrauma
卷号
38
期号
20
页码范围
2790-2800
出版商
Mary Ann Liebert, Inc., publishers
简介
Managing traumatic brain injury (TBI) patients with a cerebral perfusion pressure (CPP) near to the cerebral autoregulation (CA)-guided “optimal” CPP (CPPopt) value is associated with improved outcome and might be useful to individualize care, but has never been prospectively evaluated. This study evaluated the feasibility and safety of CA-guided CPP management in TBI patients requiring intracranial pressure monitoring and therapy (TBIicp patients). The CPPopt Guided Therapy: Assessment of Target Effectiveness (COGiTATE) parallel two-arm feasibility trial took place in four tertiary centers. TBIicp patients were randomized to either the Brain Trauma Foundation (BTF) guideline CPP target range (control group) or to the individualized CA-guided CPP targets (intervention group). CPP targets were guided by six times daily software-based alerts for up to 5 days. The primary feasibility end-point was the …
学术搜索中的文章
J Tas, E Beqiri, RC van Kaam, M Czosnyka, J Donnelly… - Journal of neurotrauma, 2021