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Cancer and obesity prevalence are still increasing worldwide. Insulin-Like Growth Factor-1 (IGF-1) is a factor in cancer proliferation, and its increase is associated with chronic inflammation in obesity. The ketogenic diet is a trend and recently developed as a therapy for cancer and obesity. This study aimed at examining the effect of long-term ketogenic diet exposure on decreasing serum IGF-1 levels in mice. This study was a true experimental study with a post-test-only control group design. Twelve male mice (20-30 g) aged 2-3 months, randomly divided into K1 (n= 6, standard diet) and K2 (n= 6, ketogenic diet), were given diet for eight weeks ad libitum. Serum IGF-1 levels were measured post-interventionally using Enzyme-Linked Immunosorbent Assay (ELISA). Bodyweight baseline and post-intervention were also measured. Data were analyzed for normality test using Shapiro-Wilk Test, mean difference was analyzed using Independent T-test for normal distribution, and Mann-Whitney Test for abnormal distribution. Data analysis was performed using Statistic Package for Social Science Version 16. Difference (D) of body weight on K1 (11.500±7.036) g and K2 (-2.000±5.060) g with p= 0,008. Serum IGF-1 levels on K1 (138,693±23,858) ng/mL and K2 (104,705±25,458) ng/mL with p= 0,038. This study showed that a long-term ketogenic diet for eight weeks decreases serum IGF-1 levels and body weight.