作者
Jens Neu, Elizabeth A Stone, Jacob A Spies, Golo Storch, Ayaka S Hatano, Brandon Q Mercado, Scott J Miller, Charles A Schmuttenmaer
发表日期
2019/4/30
期刊
The journal of physical chemistry letters
卷号
10
期号
10
页码范围
2624-2628
出版商
American Chemical Society
简介
Determining the sequence and structure of peptides is crucial for understanding their structure–property relationships. Among many techniques, structures are typically elucidated using nuclear magnetic resonance spectroscopy and single crystal X-ray diffraction measurements. In this study, we present terahertz time-domain spectroscopy (THz-TDS) as a complementary, nondestructive technique that is sensitive to both the primary and secondary structures of tetrapeptides. Using only a few milligrams of peptide, THz-TDS spectra have been measured, some of which have been supported by density functional theory (DFT) calculations, to distinguish six tetrameric peptides with similar primary and secondary structures.
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J Neu, EA Stone, JA Spies, G Storch, AS Hatano… - The journal of physical chemistry letters, 2019