作者
Kevin P Bliden, Joseph DiChiara, Lookman Lawal, Anand Singla, Mark J Antonino, Brian A Baker, William L Bailey, Udaya S Tantry, Paul A Gurbel
发表日期
2008/8/12
期刊
Journal of the American College of Cardiology
卷号
52
期号
7
页码范围
531-533
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to examine the effect of cigarette smoking on the platelet response to clopidogrel.
Background
Response variability to clopidogrel therapy has been demonstrated. Clopidogrel is metabolically activated by several hepatic cytochrome P450 (CYP) isoenzymes, including CYP1A2. Cigarette smoking induces CYP1A2 and may, therefore, enhance the conversion of clopidogrel to its active metabolite.
Methods
Among 259 consecutive patients undergoing elective coronary stenting; 120 were on chronic clopidogrel therapy and were not loaded; and 139 were clopidogrel naïve and were loaded with 600 mg. There were 104 current smokers (CS) and 155 nonsmokers (NS). The adenosine diphosphate (ADP)-stimulated platelet aggregation (PA) was assessed by conventional aggregometry. The ADP-stimulated total and active glycoprotein (GP) IIb/IIIa expression were assessed with …
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KP Bliden, J DiChiara, L Lawal, A Singla, MJ Antonino… - Journal of the American College of Cardiology, 2008