作者
HJ Kim, BS Ye, CW Yoon, Y Noh, GH Kim, H Cho, S Jeon, JM Lee, J‐H Kim, J‐K Seong, C‐H Kim, YS Choe, KHm Lee, ST Kim, JS Kim, SE Park, J‐H Kim, J Chin, J Cho, C Kim, JH Lee, MW Weiner, DL Na, SW Seo
发表日期
2014/5
期刊
European journal of neurology
卷号
21
期号
5
页码范围
744-751
简介
Background and purpose
The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized.
Methods
Forty‐five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited.
Results
Compared with NC, patients with PiB(−) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(−) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients …
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HJ Kim, BS Ye, CW Yoon, Y Noh, GH Kim, H Cho… - European journal of neurology, 2014