作者
Sina Tavakoli, Reto Asmis
发表日期
2012/12/15
来源
Antioxidants & redox signaling
卷号
17
期号
12
页码范围
1785-1795
出版商
Mary Ann Liebert, Inc.
简介
Significance: Despite the recent decline in the prevalence of cardiovascular diseases, atherosclerosis remains the leading cause of death in industrialized countries. Monocyte recruitment into the vessel wall is a rate-limiting step in atherogenesis. Death of macrophage-derived foam cells promotes lesion progression and the majority of acute complications of atherosclerotic disease (e.g., myocardial infarction) occur in lesions that are intensely infiltrated with monocyte-derived macrophages, underlining the critical roles monocytes and macrophages play in this complex chronic inflammatory disease. Recent Advances: A rapidly growing body of literature supports a critical role for reactive oxygen species (ROS) in the regulation of monocyte and macrophage (dys)function associated with atherogenesis and macrophage death in atherosclerotic plaque. Critical Issues: In this review we highlight the important roles of …
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S Tavakoli, R Asmis - Antioxidants & redox signaling, 2012