作者
Francesco Patti, Alessandra Nicoletti, Silvia Messina, Elisa Bruno, Salvatore Lo Fermo, Graziella Quattrocchi, Clara Grazia Chisari, Davide Maimone, Sabina Cilia, Mario Zappia
发表日期
2015/4
期刊
Journal of neurology
卷号
262
页码范围
923-930
出版商
Springer Berlin Heidelberg
简介
Cognitive impairment (CIm) is a frequent finding in multiple sclerosis (MS) affecting up to 65 % of patients. The aim of this study was to evaluate the prevalence and incidence of CIm in a population-based cohort of MS patients identified in the city of Catania from 1995 to 2004. One-hundred and twenty-five patients experiencing the onset of MS during 1995–2004 were enrolled. Cognitive performance was assessed through the Brief Repeatable Battery (BRB) of neuropsychological tests and the Stroop word-color task (ST). CIm was defined as the failure on at least three tests involving at least two different domains. Patients without CIm at baseline were followed up after over 3 years. The most impaired tests were the Symbol Digit Modalities Test (36 %) and the Paced Auditory Serial Addition Test 3 (35 %). At baseline the prevalence of CIm was 44 % (95 % CI 35.2–53.1). An almost sixfold increased risk of …
引用总数
201520162017201820192020202120222023202412781154564